Author

Denis Kleverov

Washington University in St. LouisORCID 0009-0002-1362-486XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:deconvolution· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

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Alexey SerdyukoviD· 1 shared Ekaterina AladyevaiD· 1 shared Maxim N. ArtyomoviD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperBioinformatics

Alexey SerdyukovORCID

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1 paper

Recent·Most cited

BioinformaticsGenome biologyPeer-reviewedJan 14, 2026

Non-negative matrix factorization and deconvolution as dual simplex problem

Denis Kleverov, Ekaterina Aladyeva, Alexey Serdyukov, Maxim N. Artyomov

This paper reformulates non-negative matrix factorization as a dual simplex problem, improving decomposition accuracy in both image and biological data.

DOI 10.1186/s13059-025-03910-1

bulk RNA-seqscRNA-seq

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