Maxim N. Artyomov

This paper develops a flow cytometry gating strategy using CD55, CD319, and CX3CR1 to identify transcriptionally defined CD8 T cell subpopulations, improving resolution over conventional methods.

This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.

This study shows that personalized neoantigen vaccines combined with immune checkpoint therapy and CD8-targeted cytokines effectively control B-cell lymphoma by enhancing T-cell responses and preventing dysfunction.

This study shows that CSF1R regulates monocyte differentiation and metabolism, with its blockade reducing Ly6Clow monocytes and affecting subset diversity through the hexosamine biosynthetic pathway.

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

The paper identifies complement deactivation as an immunometabolic checkpoint reduced by calorie restriction, which lowers inflammaging in humans and mice.

The paper uses multiplex imaging to track the development of T cell-APC triad neighborhoods during immune checkpoint therapy, showing their role in spatially organizing tumor immunity.

This study shows that Nox2 oxidase regulates neutrophilic inflammation in the oral cavity through Nrf2-dependent mechanisms, independent of its antimicrobial role.

This study shows that cDC1 cells prime CD8+ T cells, which then exacerbate tau-mediated neurodegeneration in mice.

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

This paper reformulates non-negative matrix factorization as a dual simplex problem, improving decomposition accuracy in both image and biological data.

This study shows that gut microbe-derived short-chain fatty acids reduce joint inflammation after alphavirus infection by modulating immune cell activity.

This study identifies nerve-associated macrophages (NAMs) as regulators of adipose homeostasis and inflammation during aging, showing their depletion accelerates inflammaging and impairs lipolysis.

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

This paper shows that Porphyromonas gingivalis proteases reduce viral load and modulate host interferon responses during RSV infection.

The paper identifies CD226high macrophages derived from MDP monocytes as a new myeloid cell type involved in lipid metabolism regulation across tissues.

Phantasus is a web-application that provides interactive gene expression analysis and access to over 84000 public datasets, enabling users to perform analysis from data loading to differential expression.

This study uses single cell transcriptomics to analyze heart failure in humans, identifying cell type-specific transcriptional changes and disease-associated states.

FGSEA estimates preranked GSEA P-values down to 10^-100 with predictable error in seconds to minutes, recovering more FDR-significant pathways across 605 GEO datasets than the Broad implementation.

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.

The paper develops a method to match control samples to case cohorts for genetic association studies without sharing genotypes, using singular value decomposition and provides an online library of controls.