Cell and nuclear size are associated with chromosomal instability and tumorigenicity in cancer cells that undergo whole genome doubling
Mathew Bloomfield, Sydney M Huth, Daniella S. McCausland, Ron Saad, Nazia Bano, Tran N. Chau, Megan L. Sweet, Nicolaas C. Baudoin, Andrew McCaffrey, Kai Fluet, Eva M. Schmelz, Uri Ben‐David, Daniela Cimini
The paper shows that cell and nuclear size in tetraploid cancer cells correlate with chromosomal instability and tumorigenicity, with smaller cells having better fitness and poorer patient survival in WGD-positive cancers.
Cancer Research · Jan 22, 2026Peer-reviewedCancer Biology