Author

Daniela Cimini

Virginia TechORCID 0000-0002-4082-4894Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andrew McCaffreyiD· 1 shared Ariel Andrew· 1 shared Brian G. GabrielliiD· 1 shared Daniella S. McCauslandiD· 1 shared Deborah NazarethiD· 1 shared Eva M. SchmelziD· 1 shared Jamal Carlos SaehiD· 1 shared Jelena UroseviciD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Andrew McCaffreyORCID

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2 papers

Recent·Most cited

Cell and nuclear size are associated with chromosomal instability and tumorigenicity in cancer cells that undergo whole genome doubling

Mathew Bloomfield, Sydney M Huth, Daniella S. McCausland, Ron Saad, Nazia Bano, Tran N. Chau, Megan L. Sweet, Nicolaas C. Baudoin, Andrew McCaffrey, Kai Fluet, Eva M. Schmelz, Uri Ben‐David, Daniela Cimini

The paper shows that cell and nuclear size in tetraploid cancer cells correlate with chromosomal instability and tumorigenicity, with smaller cells having better fitness and poorer patient survival in WGD-positive cancers.

Cancer Research · Jan 22, 2026Peer-reviewedCancer Biology

Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.

Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina A. Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew V. Jones, Yaowu He, John David Hooper, Nigel A.J. McMillan, Jelena Urosevic, Jamal Carlos Saeh, , Brian G. Gabrielli

This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.

Cell Death and Disease · Jan 8, 2025Peer-reviewedCell Biology