Author

Ioannis Paraskevaidis

University of PennsylvaniaORCID 0009-0002-2544-0814Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Constantinos KoumenisiD· 3 shared Eric S. DiffenderferiD· 3 shared Ioannis I. VerginadisiD· 3 shared Cezara ChepteaiD· 2 shared Charles‐Antoine AssenmacheriD· 2 shared James Metz· 2 shared Jufri SetianegaraiD· 2 shared Kristianna Kolker· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Constantinos KoumenisORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 22, 2026

Proton FLASH radiotherapy enhances control of triple-negative breast cancer through STING-IRF3 and CD8+ T-cell immunity

Pierre Loap, Ioannis Paraskevaidis, Cezara Cheptea…·Ioannis I. Verginadis

This study shows that FLASH proton radiotherapy enhances antitumor immunity and tumor control in triple-negative breast cancer by activating STING-IRF3 pathways and CD8+ T-cell responses.

DOI 10.64898/2026.09.19.751623

mouseexperimental assay

Cell BiologybioRxivPreprintAug 20, 2026

Fractionated proton and photon FLASH irradiation mitigates radiation-induced lymphopenia through kinetic sparing of circulating lymphocytes

Cezara Cheptea, Pierre Loap, Andrew Friberg…·Ioannis I. Verginadis

This study shows FLASH irradiation reduces radiation-induced lymphopenia in mice by sparing circulating lymphocytes, with durable CD8 T cell preservation across proton and photon modalities.

DOI 10.64898/2026.08.15.744675

mousestatistical model

Cell BiologyRadiotherapy and OncologyPeer-reviewedJan 27, 2025

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.

Ioannis I. Verginadis, Anastasia P. Velalopoulou, Michele M. Kim…·Theresa M. Busch

38 citationstop 1%

mouseexperimental assay