Eric S. Diffenderfer

Proton FLASH radiotherapy enhances control of triple-negative breast cancer through STING-IRF3 and CD8+ T-cell immunity

This study shows that FLASH proton radiotherapy enhances antitumor immunity and tumor control in triple-negative breast cancer by activating STING-IRF3 pathways and CD8+ T-cell responses.

Decreased Damage for proton FLASH vs Conventional Dose Rates in Mouse Jejunum Shown by Quantitative Assessment of γ-H2AX

This study compares DNA damage in mouse jejunum after FLASH and conventional proton irradiation, finding FLASH reduces DNA damage even in hypoxic regions, suggesting oxygen-independent sparing effects.

Fractionated proton and photon FLASH irradiation mitigates radiation-induced lymphopenia through kinetic sparing of circulating lymphocytes

This study shows FLASH irradiation reduces radiation-induced lymphopenia in mice by sparing circulating lymphocytes, with durable CD8 T cell preservation across proton and photon modalities.

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.