Constantinos Koumenis

This study shows that FLASH proton radiotherapy enhances antitumor immunity and tumor control in triple-negative breast cancer by activating STING-IRF3 pathways and CD8+ T-cell responses.

This study compares DNA damage in mouse jejunum after FLASH and conventional proton irradiation, finding FLASH reduces DNA damage even in hypoxic regions, suggesting oxygen-independent sparing effects.

This study shows FLASH irradiation reduces radiation-induced lymphopenia in mice by sparing circulating lymphocytes, with durable CD8 T cell preservation across proton and photon modalities.

This study shows that PARP11-induced MARylation and ubiquitination of MHC-I in cancer cells promotes immunosuppression, tumor growth, and resistance to therapies.

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

This study shows that activation of the integrated stress response (ISR) drives tumor evolution and therapy resistance by promoting dedifferentiation and stemness in lung adenocarcinoma.

FLASH proton radiotherapy improves normal tissue toxicity without compromising anti-tumor efficacy by coordinating IFN-I signaling across stromal, immune, and revSC networks.