Cell BiologybioRxivPreprint
Conformation governs cellular behaviors of LRRK2 Parkinson's disease variants
Kathryn S Hatch, Katherine J Surridge, Wei Gai…·Samara L Reck-Peterson
This study identifies 'unlatching' as a common mechanism for Parkinson's disease-associated LRRK2 variants, showing increased membrane localization and decreased S935 phosphorylation.
DOI 10.64898/2026.10.30.763152