Tolga Düz

The paper investigates the molecular mechanisms of comedogenesis in human acne using single-cell transcriptomics, identifying a microcomedone-like cell population and supporting the comedone switch hypothesis.

The paper develops an integrated single-cell and spatial transcriptomics atlas of healthy human skin, focusing on the pilosebaceous unit, and identifies previously under-characterized cell types and signaling hubs.

The paper benchmarks differential transcript usage analysis tools across static and dynamic conditions, finding optimal tools for different data types and experimental settings.