Fernando C. García Olivera

Proteome-based investigation of O-GlcNAcylation in a C. elegans model of Ageing and Alzheimer's disease: Functional Support for Earlier Hypothesis-Generating Findings

This study identifies O-GlcNAc-modified proteins in C. elegans and a tauopathy model, showing developmental regulation and disruption in the model, with PDI-2 as a candidate regulator of proteostasis.

Tracking of in vivo O-GlcNAcylation in an Alzheimer's Disease and Aging C. elegans Model

The paper tracks O-GlcNAcylation changes in C. elegans models of Alzheimer's Disease and aging, showing age-dependent increases in wild-type worms and declines in the AD model, with altered trafficking dynamics in transgenic nematodes.