Targeting Protease-activated Receptor 4 (PAR4) Protects Against Acute Kidney Injury (AKI) in Ischemia Reperfusion Injury
Emma M. Webb, Shirong Cao, Yu Pan, Mingzhi Zhang, Raymond Clement Harris, Olivier G. Boutaud, Jacob L. Bouchard, Carrie K. Jones, Craig W. Lindsley, Heidi E. Hamm
This study shows that PAR4 antagonism reduces AKI severity and improves survival in an IRI mouse model.
bioRxiv · Mar 30, 2026 · PreprintPharmacology & Toxicology