Author

Benedetto Grimaldi

Italian Institute of TechnologyORCID 0000-0002-2589-9302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Ana Isabel GuijarroiD· 1 shared Cheryl A. HawkesiD· 1 shared Donatella VecchioiD· 1 shared Elena JachettiiD· 1 shared Francesco CreaiD· 1 shared Ilaria AlborelliiD· 1 shared Irene FischettiiD· 1 shared Mario Paolo ColomboiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Ana Isabel GuijarroORCID

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2 papers

Recent·Most cited

EZH2 inhibition enhances the activity of platinum chemotherapy in aggressive variant prostate cancer

Maryam Latarani, Perla Pucci, Mark Eccleston, Massimiliano Manzo, Priyadarsini Gangadharannambiar, Irene Fischetti, Ilaria Alborelli, Vera Mongiardini, Namra Mahmood, Mario Paolo Colombo, Benedetto Grimaldi, Sushilaben H. Rigas, Shusuke Akamatsu, Cheryl A. Hawkes, Yuzhuo Z. Wang, , Francesco Crea

This study shows that EZH2 inhibition enhances platinum chemotherapy effectiveness in aggressive variant prostate cancer by reducing H3K27me3 and modulating DNA repair and apoptosis pathways.

Epigenomics · Jan 29, 2025Peer-reviewedPharmacology & Toxicology

MYC-associated factor MAX is an essential regulator of the clock core network

Olga Blaževitš, Nityanand B. Bolshette, Donatella Vecchio, Ana Isabel Guijarro, Ottavio Croci, Stefano Campaner, Benedetto Grimaldi

This study identifies MAX as a repressive component of the circadian clock core network, essential for maintaining circadian rhythms and balancing molecular clock elements.

bioRxiv · Sep 18, 2019 · PreprintMolecular Biology