ETV4 restrains the formation of CD74+ cytotoxic exhausted CD8+ T cells
Dong-Wook Lee, Yewon Kim, Hyeonmin Gil, Jiyun Lee, Yoon Ha Choi, Min-Jung Kang, Yunjung Hur, Youngkwon Song, Jong Seok Park, Kwang Soon Kim, Jong Kyoung Kim, Yoontae Lee
The paper identifies ETV4 as a transcription factor that restricts cytotoxic exhausted CD8+ T cell differentiation and shows CD74+ Tex cells correlate with improved survival.
bioRxiv · Oct 2, 2025 · PreprintImmunology