Author

Simon L. Holtbrügge

Ruhr University BochumORCID 0009-0002-4182-4367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Assay:multiome· 1 Assay:protein structure· 1

Frequent Co-Authors

Lars V. SchäferiD· 2 shared Abhishek Kalarikkal· 1 shared Arnulf RosspeintneriD· 1 shared Dominik Gendreizig· 1 shared Enrica BordignoniD· 1 shared Laura GalazzoiD· 1 shared Saumyak MukherjeeiD· 1 shared Svetlana KucheriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBiophysics

Lars V. SchäferORCID

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2 papers

Recent·Most cited

Robust Estimation of Rotational Diffusion Tensors of Proteins from Molecular Dynamics Simulations

Simon L. Holtbrügge, Lars V. Schäfer

This paper develops a method to estimate rotational diffusion tensors of proteins from MD simulations and validates it using BD simulations, finding ubiquitin exhibits nearly semi-isotropic diffusion.

The Journal of Chemical Physics · Aug 8, 2025Peer-reviewedBiophysics

A combined approach to extract rotational dynamics of globular proteins undergoing liquid-liquid phase separation

Dominik Gendreizig, Abhishek Kalarikkal, Simon L. Holtbrügge, Saumyak Mukherjee, Laura Galazzo, Svetlana Kucher, Arnulf Rosspeintner, Lars V. Schäfer, Enrica Bordignon

This study combines molecular dynamics simulations and EPR spectroscopy to measure rotational diffusion changes in γD-crystallin during liquid-liquid phase separation.

The Journal of Physical Chemistry B · Jan 16, 2025Peer-reviewedBiophysics