The paper compares three proteomic platforms in a multi-ethnic Asian cohort, finding limited overlap, platform-specific performance metrics, and ethnicity-related protein differences.

bioRxiv · Oct 24, 2025 · PreprintBioinformatics

A Complete Telomere-to-Telomere Diploid Reference Genome for Indian Population

Prasad Sarashetti, Josipa Lipovac, Jia Qi, Ling Wang, Zhe Li, Lovro Vrček, Ying Chen, Fei Yao, YY Sia, Dehui Lin, Xinyi Zhang, Daniel Muliaditan, Hwee Meng Low, See Ting Leong, Chiea Chuen Khor, , Jianjun Liu

The paper presents a high-quality, gapless diploid reference genome for an Indian population, revealing extensive structural variation and improved performance for genomic analysis in South Asian samples.

bioRxiv · Jul 12, 2025 · PreprintGenomics

Scaling Precision Medicine: Singapore's PRECISE-SG100K Genomic Engine

Claire Bellis, Gabriel Kolle, Jacklyn Yong, Maxime Hebrard, Bitong Clarabelle Alexandrine Lin, Tat Hung Koh, Paul CP Cheng, Shakita Sunmugam, K. Heng, Zhicheng Xie, Wee Yang Meah, Xiao Yin Chen, Erin Yi Ting Lim, Jyn Ling Kuan, Rudi Alberts, , Patrick B. O. Tan

The paper describes the development of a national genomic infrastructure in Singapore to scale precision medicine, achieving high throughput and operational efficiency in genome sequencing.

bioRxiv · Mar 13, 2025 · PreprintGenomics