Pritesh Jain

High-throughput plasma proteomic platforms: Insights from a multi-ethnic Asian cohort

The paper compares three proteomic platforms in a multi-ethnic Asian cohort, finding limited overlap, platform-specific performance metrics, and ethnicity-related protein differences.

Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations

The paper identifies DNA methylation biomarkers predictive of Type-2 diabetes in Asian populations and shows their utility in risk stratification.

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac risk

This study identifies 194 epigenome-wide significant CpGs associated with dilated cardiomyopathy (DCM) and links them to cardiac gene expression and cardiovascular risk factors.

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.

The paper uses Mendelian randomization to identify causal links between blood biomarkers and subcortical brain structure volumes, finding associations with specific proteins, metabolites, and biological processes.

PheWAS and cross-disorder analyses reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders.

The paper conducts a PRS-PheWAS analysis of 11 autoimmune disorders using UK Biobank data, identifying 554 significant phenotypic associations and five genetic factors.

Phenomic Network Analysis for Depression Reveals Comorbidity Architecture, Genomic Relationships, and Pleiotropic Variants

This study uses UK Biobank data to analyze genetic and phenotypic connections between depression and other traits, identifying causal relationships and pleiotropic variants.

Genome-wide Association Study identifies two novel loci for Gilles de la Tourette Syndrome

This study identifies two novel genetic loci associated with Tourette Syndrome through a genome-wide meta-analysis and integrates functional data to implicate specific genes.