Giulia Scarcella Cancelliero

This paper reviews and analyzes 359 studies on β-amyloid toxicity in SH-SY5Y cells, finding that toxicity depends on Aβ concentration, exposure time, and aggregation state, not cell differentiation.

In validated multicenter replications, 20 to 44% of 45 published Brazilian MTT, RT-PCR and elevated plus maze experiments replicated, depending on criterion; replication effects were usually smaller.