DNA Combing versus DNA Spreading and the Separation of Sister Chromatids
Alice Meroni, Sophie E. Wells, Carmen Fonseca, Arnab Ray Chaudhuri, Keith W. Caldecott, Alessandro Vindigni
The paper compares DNA combing and spreading techniques to determine their ability to resolve sister chromatids during DNA replication, finding that DNA combing can detect strand-specific alterations while DNA spreading cannot.
The Journal of Cell Biology · Jan 23, 2024Peer-reviewedMolecular Biology