Alessandro Vindigni

The paper shows BRCA1-A complex restricts replication fork reversal in ATM-deficient cells, leading to hypersensitivity to Topoisomerase I inhibitors and resistance to PARP1 inhibitors.

This study investigates how FET proteins and PARylation affect replication fork dynamics and genome stability upon PARG inhibition.

The paper shows condensin and topoisomerases work together to relieve topological stress at stalled replication forks in yeast and human cells.

The paper compares DNA combing and spreading techniques to determine their ability to resolve sister chromatids during DNA replication, finding that DNA combing can detect strand-specific alterations while DNA spreading cannot.

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.