Carmen Fonseca

This study identifies TAOK1 as a regulator of replication fork stability in BRCA1/2-deficient tumors, showing it enhances sensitivity to PARPi and IR through PCNA and ISG15 interactions.

This study shows that FIGNL1 inhibits homologous recombination in BRCA2-deficient cells by preventing RAD51 filament removal, maintaining genome stability and viability.

The paper compares DNA combing and spreading techniques to determine their ability to resolve sister chromatids during DNA replication, finding that DNA combing can detect strand-specific alterations while DNA spreading cannot.