NeuroscienceeLifePeer-reviewed
Hyperactivity of mTORC1 and mTORC2-dependent signaling mediate epilepsy downstream of somatic PTEN loss.
Erin R. Cullen, Mona Safari, Isabelle Mittelstadt, Matthew C. Weston
This study shows that both mTORC1 and mTORC2 hyperactivity contribute to epilepsy caused by somatic PTEN loss, and that inhibiting both complexes can normalize brain activity.
16 citations