Mona Safari

This study examines synapse function in thalamic regions of Dravet syndrome mice before, during, and after seizures, revealing persistent input- and cell-type-specific synaptic deficits in adulthood.

This study shows that both mTORC1 and mTORC2 hyperactivity contribute to epilepsy caused by somatic PTEN loss, and that inhibiting both complexes can normalize brain activity.

This study examines how a KCNT1 gain-of-function variant affects SST and PV GABAergic neurons, revealing differential functional outcomes and potential pathogenic mechanisms in DEEs.

This study compares synaptic and intrinsic properties of VPL and VPM thalamus neurons in mice, finding functional differences in their excitatory and inhibitory inputs and firing behavior.

This paper investigates how NaV1.1 haploinsufficiency affects thalamocortical circuit function in a Dravet syndrome mouse model, revealing input-specific synaptic and intrinsic changes in thalamic neurons.