A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1
Joanna Koszela, Anne C. Rintala‐Dempsey, Giulia Salzano, V.S.C. Pimenta, Outi Kämäräinen, Mads Gabrielsen, Aasna L. Parui, Gary S. Shaw, Helen Walden
This study identifies a conserved region in Parkin that mediates its interaction with Miro1, explaining how Parkin targets and ubiquitinates this mitochondrial GTPase.
The Journal of Cell Biology · May 14, 2025Peer-reviewedBiochemistry