Helen Walden

Building Inclusive Leadership: A Biosciences Approach

The paper develops an Inclusive Leadership Programme for bioscientists to foster autonomy and inclusivity in research environments, showing it normalizes self-perception distributions and provides a baseline for best practices.

A phosphorylation-dependent mechanism controls splice variant-specific S-palmitoylation of cardiac Kv4.3

This paper identifies a phosphorylation-dependent mechanism that regulates splice variant-specific S-palmitoylation of Kv4.3, showing how phosphorylation at S538 primes palmitoylation at C546/547 and modulates channel function.

Discovery of a FANCD2-interacting protein motif (DIP-box) linking DNA Damage Response processes

The paper identifies a FANCD2-interacting protein motif (DIP-box) that mediates DNA repair by recognizing linear motifs in repair proteins.

A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1

This study identifies a conserved region in Parkin that mediates its interaction with Miro1, explaining how Parkin targets and ubiquitinates this mitochondrial GTPase.

Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279

The paper investigates the mechanism of action of the USP1 inhibitor KSQ-4279 using biochemical assays and cryo-EM, showing it binds to the same site as ML323 but alters protein structure differently.