Jiangbo Wu

Lattice Instability Drives Formation of Protofilament Clusters at the Microtubule Plus End Tips

This paper develops a coarse-grained model to study protofilament clustering at microtubule plus-end tips, showing lattice instability drives PF cluster formation and dynamics.

Adaptations in Plasmodium tubulin determine unique microtubule architectures, mechanics and drug susceptibility

This study identifies how Plasmodium tubulin adaptations lead to distinct microtubule structures, mechanics, and drug susceptibility compared to mammalian microtubules.

On the Curvature and Relaxation of Microtubule Plus-endTips

This study uses multiscale modeling to show that microtubule plus-end tips bend outward into curved structures regardless of GTP hydrolysis state, challenging existing models linking curvature to nucleotide state.

Data-Driven Equation-Free Dynamics Applied to Many-Protein Complexes: The Microtubule Tip Relaxation

This paper uses an equation-free method to accelerate all-atom simulations of microtubule tips, revealing structural differences between GDP- and GTP-bound states.

Activation of the influenza B M2 proton channel (BM2)

This study uses molecular dynamics simulations to investigate the pH-dependent conformational changes in the influenza B M2 proton channel and elucidates the role of histidine residues in its symmetric proton conduction.