NeurosciencebioRxivPreprint
Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 modulates the motivation to chronically self-administer nicotine
Burt M. Sharp, Qin Li Jiang, Panjun Kim, Hao Chen
This study inactivates PDE4B in rat nucleus accumbens shell using CRISPR/Cas9 and shows it increases nicotine self-administration motivation despite higher effort requirements.
DOI 10.1101/2023.03.07.531588