Author

Fan Nie

Xiangtan UniversityORCID 0009-0002-9172-0822Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:variant calling· 4 Assay:whole-genome sequencing· 4 Approach:statistical model· 3 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Hansen Chen· 2 shared Feng LuoiD· 1 shared Jianxin WangiD· 1 shared Jianxin WangiD· 1 shared Jianxin WangiD· 1 shared Jianxin Wang· 1 shared Jun ZhangiD· 1 shared X J Shi· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

9 top collaborators · 8 mutual co-author links

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2 shared papersBioinformatics

Hansen Chen

Mutual co-authors in cluster

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4 papers

Recent·Most cited

RefLA: Efficient reference-guided genome assembly from long reads

X J Shi, Hansen Chen, Fan Nie, Jianxin Wang

RefLA improves genome assembly speed and quality by using a reference genome to guide long-read assembly, outperforming both de novo and fast assemblers.

bioRxiv · Dec 25, 2025 · PreprintBioinformatics

An accurate phasing tool via high-quality heterozygous variations

Jun Zhang, Fan Nie, Jianxin Wang

The paper introduces a phasing tool that improves accuracy by prioritizing high-quality variants and benchmarks it against existing methods on nine datasets.

bioRxiv · Dec 23, 2025 · PreprintBioinformatics

HapBridge: A Methylation-Guided Approach for Correcting Switch Errors and Bridging Phased Blocks in Long-Read Phasing

Hansen Chen, Fan Nie, Feng Luo, Jianxin Wang

HapBridge improves haplotype phasing by correcting switch errors and bridging phased blocks using DNA methylation signals, achieving higher accuracy and contiguity in long-read sequencing.

bioRxiv · Nov 7, 2025 · PreprintBioinformatics

LRMD: Reference-Free Misassembly Detection Based on Multiple Features from Long-Read Alignments

Xianfeng Shi, Fan Nie, Jianxin Wang

LRMD detects misassemblies in genome assemblies using long-read alignments without a reference, improving sensitivity and F1-score over existing tools.

bioRxiv · Nov 7, 2025 · PreprintGenomics