Author

Mason E Leffler

University of PennsylvaniaORCID 0009-0002-9561-0436Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Briana Abigail R. CzarneckiiD· 1 shared David W. ChristiansoniD· 1 shared Kristin R. OsikaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Briana Abigail R. CzarneckiORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintAug 31, 2026

Isoprenoid Binding and Substrate Channeling in Drimenol Synthase, a Bifunctional Class II Terpene Cyclase-Phosphatase

Kristin R. Osika, Mason E Leffler, Briana Abigail R. Czarnecki, David W. Christianson

This paper reports crystal structures of a bifunctional terpene cyclase-phosphatase enzyme and provides kinetic evidence for substrate channeling in its wild-type form.

DOI 10.64898/2026.08.29.748031

bacteria (other)structural biology

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