Kristin R. Osika

This paper reports crystal structures of a bifunctional terpene cyclase-phosphatase enzyme and provides kinetic evidence for substrate channeling in its wild-type form.

This paper investigates the mechanism of avermitilol synthase, revealing how trapped water molecules influence product specificity through structural and enzymological studies.

This study reports the crystal structure and mechanism of AsDMS, a bifunctional terpene cyclase-phosphatase, revealing its unique dual activity and substrate promiscuity.