Michael Robinson

This study investigates how disease-causing mutations in SHP-1 and SHP-2 affect WPD-loop dynamics and catalysis, revealing their role in altering enzyme function and providing insights for targeted therapy.

This paper describes an engineered archaeal PTP with enhanced thermostability and unique biochemical properties, revealing insights into enzyme evolution and biotechnological potential.

The paper identifies a triple-deletion mutant of SRC kinase that alters activation loop dynamics, leading to changes in substrate preference and signaling outcomes.