Genome expansions and regulatory contact entanglement help preserve ancestral metazoan synteny
Yehor Tertyshnyk, Thea F. Rogers, Darrin T. Schultz, Satoshi Takenawa, Bibudha Parasar, Fatih Sarigol, Abidin Erdost Irmak, Lynn Wachelder, Florian Stallovits, Jiesi Gang, Koto Kon‐Nanjo, Tetsuo Kon, Frédéric Bantignies, Longzhi Tan, Oleg Simakov
The paper investigates how genome expansion in Hydra vulgaris affects chromatin loops and regulatory interactions, finding that it preserves ancestral synteny through entangled long-range regulatory configurations.
bioRxiv · Apr 15, 2026 · PreprintEvolutionary Biology