Longzhi Tan

This study identifies a brain-specific neuronal population critical for viable pregnancy by analyzing gene expression changes in estrogen receptor alpha-expressing neurons during gestation.

This study identifies Rpl3l as a muscle-specific ribosomal protein that regulates chromatin insulation in atrial cardiomyocytes, linking genome structure to cardiac rhythm stability.

The paper introduces Plate-C, a high-throughput method for whole-genome 3D architecture profiling, and identifies modulators of DNA structure across multiple biological pathways and cell types.

The paper investigates how genome expansion in Hydra vulgaris affects chromatin loops and regulatory interactions, finding that it preserves ancestral synteny through entangled long-range regulatory configurations.

The paper uses single-cell 3D genome mapping to show cohesin-mediated loop extrusion forms transcription elongation loops that enhance transcriptional burst frequency.

The paper develops 3D genome atlases for human and mouse cerebellar granule cells across lifespan, revealing non-neuronal 3D genome architecture remodeling.

The paper shows that opposing epigenetic forces in olfactory progenitors spatially restrict stochastic OR choice through transcription and silencing influenced by NFIA, B, and X gradients.

The paper identifies two enhancers critical for TAAR gene expression in olfactory sensory neurons and shows they operate in cis to regulate gene choice.

The paper generates transcriptome and 3D genome atlases of developing mouse brain cells, revealing structure-type-based cell identity and experience-independent developmental changes.

The paper shows that zonal olfactory receptor expression in mice is regulated by chromatin structure, genome architecture, and NFIA/B/X gradients, with dorsal ORs being silenced in ventral zones.

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

The paper maps zonal expression of olfactory receptors in mouse MOE using mRNA sequencing, identifying zones for 1,033 OR genes with high coverage and accuracy.