Cell BiologyThe Journal of Cell BiologyPeer-reviewed
PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum
Nicala Jenkins, Zainab Adamji, Maria R. Narciso…·Roberto J. Botelho
The paper shows PIKfyve regulates ER dynamics by balancing phosphoinositides at ER-lysosome contacts, affecting lysosome fission and ER morphology.