Switching Metazoan Fatty Acid Synthase Between Reducing and Non-reducing Elongation Mode via Programming of the Ketoreductase Domain
Damian L. Ludig, André Herber, Martin Grininger
This study engineers metazoan fatty acid synthase to switch from reducing to non-reducing elongation mode by modifying the ketoreductase domain, producing pyrone intermediates.
ChemBioChem · Jan 1, 2026Peer-reviewedBiochemistry