Martin Grininger

Switching Metazoan Fatty Acid Synthase Between Reducing and Non-reducing Elongation Mode via Programming of the Ketoreductase Domain

This study engineers metazoan fatty acid synthase to switch from reducing to non-reducing elongation mode by modifying the ketoreductase domain, producing pyrone intermediates.

Identification of pseudotetraivprolide from Pseudomonas entomophila give novel insights into the biosynthesis of detoxin/rimosamide-like anti-antibiotics

The paper identifies pseudotetraivprolide from Pseudomonas entomophila, elucidates its biosynthesis, and reveals the function of conserved hypothetical proteins in its production.

The Kinetics of Carbon-Carbon-Bond Formation in Metazoan Fatty Acid Synthase and its Impact on Product Fidelity

The paper investigates the kinetics of carbon-carbon bond formation in fatty acid synthase, revealing how the enzyme's activity and fidelity are influenced by substrate length and dimeric cooperativity.

Molecular mechanisms in fungal fatty acid synthase (FAS) assembly

This study investigates the molecular mechanisms of fungal fatty acid synthase (FAS) assembly, revealing a pathway of domain-domain interactions that underlies its quaternary structure formation.