BiochemistryACS CatalysisPeer-reviewed
Multi-Objective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance
Martin Toul, Veronika Slonková, Jan Mičan…·Zbyněk Prokop
This paper designs next-generation thrombolytic proteases with improved catalytic efficiency, fibrin selectivity, and inhibition resistance through multi-objective enzyme engineering.
DOI 10.1021/acscatal.6c02903