Author

Ethan Paulаkonis

University of North Carolina at Chapel HillORCID 0009-0003-0494-8384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Jonathan Cummings SchisleriD· 2 shared Michael Fernandes de AlmeidaiD· 2 shared Nicholas Gene BrowniD· 2 shared Richard C. PageiD· 2 shared Adeleye James AfolayaniD· 1 shared Aliyaa Pathan· 1 shared Change-he Shi· 1 shared Chathura PaththamperumaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Jonathan Cummings SchislerORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 26, 2025

Domain-specific decoupling of co-chaperone and ligase functions in STUB1 underlies biochemical and clinical heterogeneity in SCA48

Selin Altınok, Ethan Paulаkonis, Michael Fernandes de Almeida…·Jonathan Cummings Schisler

This study identifies how STUB1 mutations in SCA48 disrupt co-chaperone and ligase functions in a domain-specific manner, leading to clinical heterogeneity.

DOI 10.1101/2025.11.26.690709

humanbulk RNA-seq

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BiochemistrybioRxivPreprintFeb 17, 2025

Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering

Mariah S. Stewart, Chathura Paththamperuma, Colleen M. McCann…·Jonathan Cummings Schisler

This study examines how phosphorylation at HSP70 T636 affects its binding to CHIP, showing reduced affinity and altered interactions with other co-chaperones, with implications for disease.

1 citation

protein structureexperimental assay

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