Jonathan Cummings Schisler

This study shows trametinib causes mitochondrial injury and innate immune activation in mouse hearts, leading to cardiomyopathy and heart failure.

This study identifies how STUB1 mutations in SCA48 disrupt co-chaperone and ligase functions in a domain-specific manner, leading to clinical heterogeneity.

This study examines how phosphorylation at HSP70 T636 affects its binding to CHIP, showing reduced affinity and altered interactions with other co-chaperones, with implications for disease.

This study uses synergistic MAPT mutations to create a model for tau aggregation, identifying Hsp70 as a key driver and showing its impact on neuronal function.

The paper identifies a lncRNA signature associated with SARS-CoV-2 infection through transcriptomic analysis and functional correlation studies.

The paper identifies genomic associations with ex vivo DNA damage responses to ionizing radiation in mice, highlighting pathway differences across radiation types and timing.

This study investigates how SARS-CoV-2 infection affects mitochondrial gene expression in different tissues and disease stages, finding targeted inhibition in some organs and upregulation in others.

The paper identifies miR-2392 as a miRNA involved in SARS-CoV-2 infection, showing its role in inflammation, glycolysis, and hypoxia, and develops a miRNA-based therapeutic targeting it.

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

This study investigates how CHIP mutations in SCAR16 patients correlate with clinical phenotypes and biochemical changes, identifying potential therapeutic targets.

The paper examines how TAS2R38 genetic variants affecting bitter taste perception influence vegetable intake in response to different dietary interventions.