NeuroscienceNeurobiology of DiseasePeer-reviewed
Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons
Madison R. Glass, Dosh Whye, Nickesha Camille Anderson…·Mustafa Şahin
This study compares neuronal activity and gene expression in CDD patient-derived neurons from two differentiation methods, finding early hyperexcitability in organoid-derived neurons but not induced neurons.
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