The paper creates a cellular and spatial map of the duodenum in children, revealing environmental and developmental influences on intestinal cell states.

bioRxiv · Dec 17, 2025 · PreprintDevelopmental Biology

Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

Madison R. Glass, Dosh Whye, Nickesha Camille Anderson, Delaney Wood, Nina R. Makhortova, Taryn J. Polanco, Kristina H. Kim, Kathleen E. Donovan, Gayathri Rajaram Srinivasan, Lorenzo Vaccaro, Ashish Jain, Davide Cacchiarelli, Liang Sun, Heather E. Olson, Elizabeth D. Buttermore, Mustafa Şahin

This study compares neuronal activity and gene expression in CDD patient-derived neurons from two differentiation methods, finding early hyperexcitability in organoid-derived neurons but not induced neurons.

Neurobiology of Disease · Sep 8, 2025Peer-reviewedNeuroscience

An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma

Annegret Holm, Matthew S. Graus, Jill Wylie‐Sears, Jerry Wei Heng Tan, Maya Alvarez-Harmon, Luke Borgelt, Sana Nasim, Long Hoa Chung, Ashish Jain, Mingwei Sun, Liang Sun, Pascal Brouillard, Ramrada Lekwuttikarn, Yanfei Qi, Joyce M. C. Teng, , Joyce E. Bischoff

The paper identifies a SOX18-mevalonate pathway axis in infantile hemangioma and suggests repurposing statins as a treatment.

Journal of Clinical Investigation · Feb 25, 2025Peer-reviewedMolecular Biology