Natalia Ree

This study examines how chemical mutagens affect mitochondrial DNA ploidy in iPSC cells, finding that certain mutagens cause significant changes in mitochondrial DNA content and organization.

The paper investigates the role of mitochondrial DNA repeats in aging and healthspan, finding that disrupting the common repeat reduces somatic deletions and improves healthspan.

The paper identifies a contact zone in the human mitochondrial genome where deletions are more likely, linking it to aging and lifespan.

The paper finds that aneuploidy in human embryos is linked to higher mitochondrial DNA content and more ultra-rare mtDNA variants, independent of maternal age.