A co-evolved peptide-GPCR system senses host entry to drive fungal infection
Gabriel Mendoza-Rojas, Philip Nakonz, Min Lu, Nora Marie Kühne, Johannes Postma, Naomi Shtakser, Max Heinen, Manav Patel, Orlando Argüello‐Miranda, Kai Heimel, Sonja Billerbeck, Florian Altegoer
The paper identifies a co-evolved peptide-GPCR system in Ustilago maydis that senses host entry by releasing a hidden peptide ligand from the secreted protein Pit2, promoting fungal proliferation.
Nature Communications · Oct 9, 2026Peer-reviewedMicrobiology