Molecular BiologybioRxivPreprint
Argonaute-2 slicing of a domesticated retrotransposon maintains proteostasis and prevents lethal skeletal muscle defects
Nickolas Almodovar, Caroline W Dunn, Benjamin Kleaveland
This study identifies Rtl1 as a key AGO2 slicing substrate in skeletal muscle, showing that AGO2 slicing prevents lethal skeletal muscle defects by repressing a domesticated retrotransposon.
DOI 10.64898/2026.05.22.727060