Weiyi Tang

This paper designs synthetic transmembrane subunits to stabilize and expand membrane proteins, demonstrating their utility in structural biology and disease treatment.

The paper develops a platform to measure and engineer membrane protein-protein interactions using split nanoluciferase, improving assay accuracy and compatibility with protein engineering.

The paper uses protein design to investigate the structural principles of common antiparallel transmembrane motifs, revealing how sequence patterns stabilize membrane protein architectures.