Author

Colleen A. Maillie

Scripps Research InstituteORCID 0000-0001-7050-4464Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Marco MraviciD· 2 shared Minghao ZhangiD· 2 shared Andrew B. WardiD· 1 shared Brittany B. Sanchez· 1 shared Catalina AvarvareiiD· 1 shared Charlie T. AndersoniD· 1 shared George GoldenfeldiD· 1 shared Gerard J. A. KrooniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Marco MravicORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 22, 2026

Programmed inhibition of an innate immune receptor via de novo designed transmembrane proteins

Colleen A. Maillie, Minghao Zhang, Nadia Gosiet…·Marco Mravic

This paper designs synthetic proteins that inhibit TLR4 signaling by binding its transmembrane domain, demonstrating the importance of transmembrane interactions in immune signaling.

DOI 10.1073/pnas.2536559123

humanprotein structure

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedOct 7, 2025

Design principles of the common Gly-X6-Gly membrane protein building block

Kiana Golden, Catalina Avarvarei, Charlie T. Anderson…·Marco Mravic

The paper uses protein design to investigate the structural principles of common antiparallel transmembrane motifs, revealing how sequence patterns stabilize membrane protein architectures.

3 citations

protein structuredeep learning

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