Author

Rui Yee Loke

Technical University of MunichORCID 0009-0003-5151-8360Unclaimed ORCID profile · follow to get notified of new preprints

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Biophysics· 1

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Approach:experimental assay· 1

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Enzo KoppergeriD· 1 shared Friedrich Christian SimmeliD· 1 shared Lennart J. K. WeißiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

Enzo KoppergerORCID

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1 paper

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BiophysicsbioRxivPreprintAug 18, 2026

DNA Origami Nanomechanical Amplifiers for Resolving Single-Molecule Binding Events

Rui Yee Loke, Lennart J. K. Weiß, Enzo Kopperger, Friedrich Christian Simmel

This paper introduces a DNA origami nanomechanical amplifier that translates molecular conformational changes into measurable mechanical displacements, enabling single-molecule analysis of binding events without labeling or fluorescence.

DOI 10.64898/2026.08.11.743830

experimental assay

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