Vincent Armand

The paper identifies new compounds binding at the histamine site of the NMDA receptor, including a partial agonist and antagonist with nanomolar affinity, suggesting their potential as antipsychotics for schizophrenia and other disorders.

This study investigates the interaction between H1 and NMDA receptors, showing that inverse agonists delay NMDA current rundown, potentially contributing to proconvulsant effects.