Author

Shehani Kahawatte

University of CincinnatiORCID 0009-0003-6997-0507Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Organism:Drosophila· 1 Approach:graph neural network· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Ruxandra I. DimaiD· 2 shared Amanda C. MackeiD· 1 shared Carter St. Clair· 1 shared Jennifer L. RossiD· 1 shared Madhavie Ranpati DewageiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Ruxandra I. DimaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsThe Journal of Chemical PhysicsPeer-reviewedSep 16, 2026

Distinct Tubulin C-Terminal Tails Control the Efficiency of a Microtubule Severing Machine

Madhavie Ranpati Dewage, Shehani Kahawatte, Jennifer L. Ross, Ruxandra I. Dima

This study investigates how different tubulin CTT isotypes influence katanin structure and dynamics, revealing that inhibitory CTTs enhance pore narrowing and flexibility, while non-inhibitory CTTs disrupt coordination.

DOI 10.1063/5.0345522

mechanistic / dynamical modelchromatin & epigenetic regulation

𝕏 PostBluesky

BiophysicsBiochemistryPeer-reviewedFeb 26, 2025

A major disease-related point mutation in spastin alters dramatically the dynamics and allostery of the motor

Shehani Kahawatte, Amanda C. Macke, Carter St. Clair, Ruxandra I. Dima

This study uses molecular dynamics and machine learning to analyze how the R591S mutation in spastin affects its dynamics and allostery, leading to impaired microtubule severing and HSP-related dysfunction.

4 citations

Drosophilaprotein structure

𝕏 PostBluesky