Author

Amanda C. Macke

University of CincinnatiORCID 0000-0001-8927-0389Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Approach:graph neural network· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Carter St. Clair· 1 shared Christian FreniereiD· 1 shared Christopher AikeniD· 1 shared Chunxiang WuiD· 1 shared Jianfeng LiniD· 1 shared Jing ChengiD· 1 shared Jiong ShiiD· 1 shared Juan R. PerillaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

Carter St. Clair

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 11, 2026

A Hybrid Gag Lattice as a Structural Intermediate in HIV-1 Maturation

Megan E. Meuser, Chunxiang Wu, Amanda C. Macke…·Yong Xiong

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

2 citations

𝕏 PostBluesky

BiophysicsBiochemistryPeer-reviewedFeb 26, 2025

A major disease-related point mutation in spastin alters dramatically the dynamics and allostery of the motor

Shehani Kahawatte, Amanda C. Macke, Carter St. Clair, Ruxandra I. Dima

This study uses molecular dynamics and machine learning to analyze how the R591S mutation in spastin affects its dynamics and allostery, leading to impaired microtubule severing and HSP-related dysfunction.

4 citations

Drosophilaprotein structure

𝕏 PostBluesky