Michael Meier

This study shows that loss of Stag1 in zebrafish impairs cell cycle progression and activates p53, but is compensated by changes in BMP signaling and metabolism.

Single-cell RNA sequencing of Botrylloides diegensis identified 29 cell clusters, revealing tissue specialization and developmental trajectories in a colonial ascidian.

The paper shows that mutations in cohesin subunits rad21 and stag2b have distinct developmental effects in zebrafish, suggesting independent roles of cohesin quantity and composition in early development.

This study shows that cohesin is essential for zygotic genome activation in zebrafish by redistributing to active genes and influencing chromosome architecture.